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Oncologists determine what kind of treatment to pursue for every patient. There are numerous options. There is no one size fits all treatment regimen for pleural mesothelioma cancer victims. This is because of the relative rareness of the disease, the high mortality rate and low treatment success rate, and the few scientific studies to provide meaningful statistics.

The prospects for mesothelioma patients have been grim, but doctors have recently made progress. Treatments for cancer are traditionally surgery (taking out the tumor and surrounding tissue), chemotherapy (poisoning cancerous cells) and radiation (killing cancer cells with radiation) There are problems with all three. Patients with mesothelioma have not responded well to traditional radiation therapy. Researchers are looking for ways of aiming radiation directly at the tumor in hopes that this will result in less damage to healthy tissue.

The mesothelial tissue around the tumor is removed by surgery. The surgery is difficult and challenging, with unknown effects or benefits to patients. The usual chemotherapy cocktails effective on other cancers are not effective on mesothelioma, and combinations of chemotherapy agents have been tried, but without much success. As with radiation, research is going toward controlling the physical location of the treatment with emphasis on the pleural cavity.

Many advanced techniques in cancer treatment are tried on mesothelioma patients because of its high fatality rate. Such treatments include anti-angiogenesis drugs like thalidomide and biologic therapies agent interleukin 2. The new drug pemetrexed (brand name Alimta) has shown good results in extending life with mesotheliomas..

Before acting, oncologists review the stage of mesothelioma, position of the tumor, and age and health status of the patient. Two exotic ways of attacking mesothelioma are gene therapy and photodynamic therapy. Clinical trials using these techniques are being offered to some of those who have mesothelioma.